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World Cord Blood Congress III, Roma, Italy, October 2011
ESH - EBMT Training Course Blood and Marrow Transplantation, La Baule, France, May 2011
ESTM Cord Blood Banking Conference, Pescara, Italy, November 2009
ESH-EBMT Training Course, Latimer, UK, May 2009
ESH-Eurocord-Netcord Cord Blood Conference, Mandelieu, France, October 2008
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Expert Q&A Forum :: Cord Blood Transplantation :: Healtcare Professionals Q&A
Question from New Dehli India
published 2011-06-23 12:28:28 by Benassy Arnaud
Question : This a patient of Thalassemia Major; age 2 yrs old needs a cord blood transplant. Cord blood of his sibling was collected and stored. Sibling was normal and fully HLA matched with patient (6/6) - was tested at 12 weeks of gestational age . Total cells stored were 25 million and weight of recipient is 12 kg. 95% cells are viable. Cell dose for recipient is 2 x 106, which is quite less. Unfortunately sib was died in first month of life and cause of death is not known. Family is desperately looking for CBT for patient. No other donor is availbale. We are looking for other match cord form banks. Please give your valuable suggestion about this patient. If we get a another match or partially mismatch cord; what should be conditioning regimen and GVHD prophylaxis ?
Answer : This patient has thalassemia major he can survive long if he receives proper care with transfusions and iron chelation therefore there is no rush for a transplant except if the family cannot do supportive care properly. It would have been useful to know he cause of death of the donor. We have been looking at the results of unrelated cord blood transplant in children with hemoglobinopathies they are not very good with a survival of 40% which is not acceptable in a disease which can be treated without transplant. May be you could discuss with the family if they want another child in that case it would be a very good indication for selection of embryos on absence of thalassemia and HLA identity. Ready to answer to any question you may have Sincerely Eliane Gluckman
Infusion of MSCs in Tandem after UCB transplant.
published 2011-11-25 11:08:42 by Nancy Hamilton
Question : What is your opinion about infusion of mesenchymal stem cells , e.g. from umbilical cord tissue, in tandem or after, a transplant of umbilical cord blood ?
Answer : Eliane Gluckman: There are several studies looking for the addition of MSC to an unrelated cord blood transplant. The source of MSC can be either cord tissue or third party adults MSC from bone marrow. The objective is to improve engraftment and decrease GVH. Most studies are phase I II and there are very few published reports. We can say that it is safe and feasible clinical efficacy must be analyzed in more patient. November 25, 2011
Success rate of Allogeneic and Autologous UCB transplant
published 2011-11-25 11:11:58 by Nancy Hamilton
Question : What is the success rate of cord blood transplantation (allogeneic and autologous)?
Answer : Eliane Gluckman: Results of allogeneic cord blood transplants have been published and can be found on our website. There are very few published cases of autologous cord blood transplant see article in Hematologica november 2011 vol96:1700-1707. by E. Gluckman et al entitled family directed umbilical cord blood bank. November 24, 2011